Syposium Schedule
Final Program
Sunday, June 7, 2009
16:00 Arrival and registration at Hyatt Regency Hotel, Jeju
18:00 Welcome Reception, Terrace Cafe, 1st Floor Hyatt Regency Hotel, Jeju
20:00 SAB Meeting, Terrace Ballroom B, Hyatt Regency Hotel, Jeju
Monday, June 8, 2009
09:00 Opening Remarks Jeongbin Yim
09:10 - 11:40 Chemistry of Pteridines
Chair: Wolfgang Pfleiderer, Hiroshi Yamamoto
(30 min) Unexpected reactions in pteridine chemistry
Wolfgang Pfleiderer, University of Konstanz, Konstanz
(20 min) Selective formation of 6-hydroxyalkylpterins
Shizuaki Murata, Nagoya University, Nagoya
(15 min) Synthetic study of methanopterin 1 introduction of amino alkyl group into C6 substituents
Yasuhiro Kuroda, Nagoya University, Nagoya
(15 min) Novel Routes to Blocked Dihydropteridines
Craig Robert McInnes, University of Strathclyde, Glasgow
10:30 – 11:00 Coffee Break
(20 min) First synthesis of a representative, natural pterin glycoside: 2’-O-(alpha-D-glucopyranosyl)biopterin
Hiroshi Yamamoto, Shujitsu University, Okayama
(20 min) Quantitative determination of both reduced and oxidized forms of biopterin by a single fluorometric HPLC
Young Shik Park, Inje University, Kimhae
11:40 - 12:10 Mechanism of Antifolate Action
Chair: Steven W. Bailey
(30 min) Molecular basis of antifolate efficacy in the treatment of chronic inflammatory diseases
Gerrit Jansen, VU Institute for Cancer & Immunology, VU University Medical Ctr, Amsterdam
12:10 - 13: 30 Lunch
13: 30 – 15:10 Mechanism and Regulation of Pteridine Biosynthesis
Chair: Jeongbin Yim, Ernst R Werner
(50 min) Hopkins Lecture
Gregory Kapatos, Wayne State University School of Medicine, Detroit
“The ups and downs of GTP cyclohydrolase I”
Chair: Nenad Blau
(30 min) Biosynthesis of aurodrosopterin, a minor red eye-pigment of Drosophila
Jeongbin Yim, Seoul National University, Seoul
(20 min) Expression of the drosophila melanogaster punch gene encoding GTP cyclohydrolase I.
Jaeseung Yoon, Kyung Hee University, Yongin-Si
15:10 - 15:40 Coffee Break
15:40 - 17:10 Dihydrofolate Reductase and Thymidylate Synthase
Chair: Wojciech Rode, Gerrit Jansen
(30 min) Pharmacogenomics of colon and non-small cell lung cancer (NSCLC): potential for tailored therapy?
Godefridus J Peters, VU University Medical Center, Amsterdam
(20 min) Cell cycle modulation enhances the cytotoxicity of thymidylate synthase inhibitors
Godefridus J Peters, VU University Medical Center, Amsterdam
(20 min) Histidine phosphorylation, or tyrosine nitration, affects thymidylate synthase properties
Wojciech Rode, Nencki Institute of Experimental Biology, Warszawa
(20 min) Methotrexate-induced senescence in human adenocarcinoma cells is associated with induced expression of p53 effector genes
Magdalena Dabrowska, Nencki Institute of Experimental Biology, Warsaw
17:10 - 17:50 Folates: Methods
Chair: Godefridus J Peters
(20 min) Determination of folate monoglutamates in biofortified rice with UPLC-MS/MS
Veerle De Brouwer, Ghent University, Ghent
(20 min) Application of microbiological assay and liquid chromatography-ionisation mass spectrometry for the profiling of rice grain folates
Riza Abilgos Ramos, University of Nottingham, School of Pharmacy, Nottingham
Tuesday, June 9, 2009
09:00 - 11:00 Tetrahydrobiopterin-dependent Enzymes
Chair: Gregory Kapatos, Aurora Martinez
(30 min) Evolution of structure, function and regulation in phenylalanine hydroxylase
Aurora Martinez, University of Bergen, Bergen
(20 min) Phosphorylated tyrosine hydroxylase formed insoluble aggregates by inhibition of ubiquitin proteasome system in NGF-differentiated PC12D cells
Ichiro Kawahata, Tokyo Institute of Technology, Yokohama
(30 min) Alkylglycerol monooxygenase candidate genes
Ernst R Werner, Innsbruck Medical University, Innsbruck
(20 min) Alkylglycerol monooxygenase: Properties of an orphan enzyme
Katrin Watschinger, Medical University Innsbruck, Innsbruck
(20 min) Direct monitoring of fatty aldehyde dehydrogenase activity by pyrenedecanal
Markus A. Keller, Innsbruck Medical University, Innsbruck
11:00 - 11:30 Coffee Break
11:30 - 12:20 Other Folate Enzymes
(50 min) Hopkins Lecture
Dean Appling, University of Texas at Austin, Austin
“Enzymology of mammalian mitochondrial one-carbon metabolism”
Chair: Barry Shane
12:20 - 13:20 Lunch
13:20 - 15:35 Clinical Aspects of Pteridines incl. PKU and BH4 Deficiency
Chair: Nenad Blau, Dong Hwan Lee
(30 min) Genotype-predicted tetrahydrobiopterin (BH4)-responsiveness and molecular genetics in Croatian patients with phenylalanine hydroxylase (PAH) deficiency
Nenad Blau, University Children's Hospital, Zurich
(20 min) Molecular and biochemical basis of tetrahydrobiopterin responsiveness in phenylketonuria
Yoshiyuki Okano, Osaka City University Graduate School of Medicine, Osaka
(20 min) BH4 responsive phenylketonuria and BH4 deficiency phenylketonuria in Korea
Dong Hwan Lee, Soonchunhyang University Hospital, Seoul
(15 min) Optimizing the use of sapropterin (BH4) in the management of phenylketonuria
Nenad Blau, University Children's Hospital, Zurich
(20 min) Lower plasma neopterin concentration in dopa-responsive dystonia patients
Hiroki Fujioka, Osaka City University Graduate School of Medicine, Osaka
(15 min) Phenylketonuria: correlations between lumbar bone mineral density and vitamin and mineral blood concentrations
Martijn de Groot, Beatrix Children's Hospital, University Medical Center Groningen, Groningen
(15 min) Gene therapy for phenylketonuria exploiting liver or muscle for phenylalanine clearance
Beat Thöny, University of Zurich, Zurich
15:35 - 16:00 Coffee Break
16:00 - 18:20 Nitric Oxide Synthase, NO Signaling and NOS Dysfunction
Chair: Steven S Gross, Hun-Taeg Chung
(30 min) Strategies to restore endothelial BH4 levels and NO synthesis as potential pharmacotherapy for diabetetic vasculopathy
Steven S Gross, Weill Cornell Medical College, New York
(30 min) Roles of heme oxygenase-1 in the antiproliferative and antiapoptotic effects of nitric oxide on jurkat T cells
Hun-Taeg Chung, Ulsan University, Ulsan
(20 min) Tetrahydrobiopterin, nitric oxide synthase and FDG microPET for monitoring the hypoxic ischemic effect in neonatal pigs
Haruo Shintaku, Osaka City University Graduate School of Medicine, Osaka
(20 min) Critical role for BH4 recycling by DHFR in regulation of eNOS coupling
Mark J. Crabtree, University of Oxford, Oxford
(20 min) Tyrosine modification of beta2-tubulin and its potential nitric oxide signaling in cardiomyogenesis
Sang Ick Park, Korea National Institute of Health (KNIH), Seoul
(20 min) Cofactor rather than antioxidative activity of tetrahydrobiopterin prevents ischemia reperfusion injury associated severe graft pancreatitis following murine pancreas transplantation
Manuel Maglione, Innsbruck Medical University, Innsbruck
19:00 Conference Dinner
Garden Party (Terrace Ballroom in case of rain)
Wednesday, June 10, 2009
08:30 - 12:00 Folate Transport and Metabolism
Chair: Richard H. Finnell, Manohar Ratnam
(30 min) Metabolic and genetic regulation of the folate-dependent methionine Cycle
Barry Shane, University of California, Berkeley
(30 min) Functional lessons derived from mutant proton-coupled folate transporters from patients with hereditary folate malabsorption
Yehuda G Assaraf, Technion-Israel Institute of Technology, Haifa
(30 min) Role of autoantibodies in cerebral folate deficiency syndrome and other pediatric disorders
Richard H. Finnell, The Texas Institute for Genomic Medicine, Houston
10:00 - 10:30 Coffee Break
(30 min) Regulation of folate receptor internalization by protein kinase C signaling
Manohar Ratnam, University of Toledo College of Medicine, Toledo
(30 min) Differential responses to folic acid versus natural 5-methyltetrahydrofolate in humans
Steven W. Bailey, University of South Alabama, Mobile
(15 min) Erythrocyte folate status in patients with thyroid and breast cancers
Hande Sİpahi, Hacettepe University, Ankara
(15 min) MTHFR, MTR, and MTRR polymorphisms in relation to p16(INK4A) gene promoter hypermethylation in colorectal mucosa and clinical outcome of patients with colorectal cancer
Yvonne Wettergren, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg
12:00 - 13:00 Lunch
Afternoon: Free for Workshops and Other Activities
Thursday, June 11, 2009
08:30 - 10:30 Other Functions of Tetrahydropterin incl. Animal Models
Chair: Beat Thöny, Hiroshi Ichinose
(30 min) Murine models of inherited pterin and monoaminergic neurotransmitter disorders
Beat Thöny, University of Zurich, Zurich
(30 min) BH4 metabolism in the brains of KO mice
Hiroshi Ichinose, Tokyo Institute of Technology, Nagoya
(20 min) New mouse models for BH4 deficiency by targeting the 6-pyruvolytetrahydropterin synthase gene Pts
Dea Adamsen, University Children's hospital, Zurich
(20 min) Sepiaptein reductase knockout mice: Biochemical and histochemical analyses
Daigo Homma, Tokyo Institute of Technology, Yokohama
(20 min) Low-dose tetrahydrobiopterin supplementation reduces atherosclerosis progression in ApoE-KO mice via effects on vascular T cell infiltration
Tim Sebastian Schmidt, Oxford University, Oxford
10:30 - 10: 50 Coffee Break
10: 50 - 11:30 Poster Presentation (Pteridine field)
(P-1) Pteridine glycosyltransferases: structure and function
Ae Hyun Kim, Inje University, Kimhae
(P-2) Hyperglycemia effect on tetrahydropteridine synthesis in Dictyostelium discoideum Ax2
Mi Bi Park, Inje University, Kimhae
(P-3) Dihydropteridine reductase (DHPR) activity in thyroid and breast cancer patients
Saziye Sezin Palabiyik, Ataturk University, Erzurum
(P-4) Screening of urinary neopterin levels in Turkish adolescents
Gözde Girgin, Hacettepe University, Faculty of Pharmacy, Ankara
(P-5) Severe PTPS deficiency in an adult lawyer with normal IQ
Marcello Giovannini, University of Milan, Milan
(P-6) 6-pyruvoyl tetrahydropterin synthase deficiency - clinical and molecular profiles of six Malaysian patients
Lock Hock Ngu, Paediatric Institiute, Hospital Kuala Lumpur, Kuala Lumpur
(P-7) Tetrahydrobiopterin/total biopterin ratio in human urine
Do Hyung Kim, Inje Universit, Kimhae
(P-8) Role of tetrahydrobiopterin in neuronal apoptosis in Drosophila melanogaster
Heuijong Kim, Seoul National University, Seoul
(P-9) Crystal structure of dictyostelium discoideum phenylalanine hydroxylase in complex with dihydrobipterin and L-norlucine (Fe (III)-BH2-NLE)
Kon Ho Lee, Gyeongsang National University, Jinju
(P-10) Uncovering enzymatic transformations involved in biosynthesis of 7-deazapurine
containing compounds
Vahe Bandarian, University of Arizona, Tucson
11:30 - 12:00 Poster Presentation (Folate Field)
(F-1) Synthesis and cytotoxicity activity of aminopyrimidine derivatives as potential dihydrofolate reductase inhibitors
Shohreh Mohebbi, Shaheed Beheshti University of Medical Sciences, School of Pharmacy, Tehran
(F-2) Synthesis and antimicrobial activity of aminopyrimidine derivatives as potential dihydrofolate reductase inhibitors
Farzad Kobarfard, Shaheed Beheshti University of Medical Sciences, School of Pharmacy, Tehran
(F-3) Crystal structure of mouse thymidylate synthase
Wojciech Rode, Nencki Institute of Experimental Biology, Warsaw
(F-4) Membrane transport properties and biological activity of stereo-isomers of glycinamide ribonucleotide formyltransferase (GARFT) inhibitors AG2032 and AG2034 Gerrit Jansen, VU University Medical Ctr, Amsterdam
(F-5) Determination of folates in tumor and adjacent mucosa of CRC patients using LC-MS/MS
Elisabeth Odin, Göteborgs Universitet, Göteborg
(F-6) Profiling of rice grain folates using microbiological assay and liquid chromatograph tandem mass spectrometry
Riza Abilgos Ramos, University of Nottingham, School of Pharmacy, Nottingham
(F-7) Approaches to the Development of Inhibitors of Parasitic Pteridine Metabolism
Niaz McGuire, University of Strathclyde, Glasgow
12:00 - 12:10 Closing Remarks, Nenad Blau
12:10 - 13:10 Lunch
Afternoon: Excursion + Dinner
Friday, June 12, 2009
09:00 - 10:30 Workshop on Inborn Errors of BH4 Metabolism
10:30 - 11:00 Coffee Break
11:00 - 12:15 Workshop on a specific folate field can be organized upon request.
12:00 - 13:00 Lunch
Afternoon: Departure
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